SCI and the liver

How did I get here?

• First couple of papers found markers of liver function add value to predictions of neurological outcomes
• Proteomic work seems to suggest something similar
• As it turns out, there be literature about it as well

The livers response to trauma

SCI promotes chronic liver steatosis

Intuition + reading = ideas

• Difference prior to injury?
  • pre-damaged liver due to lifestyle (drink/diet/etc)
  • Genetics
• Damage to sympathetic and parasympathetic signalling (T7-T12)?
• “Leaky gut” -> microbiome bacteria + toxins in blood -> unhappy liver?

Potential future work

• Reanalyse “Yakult” study data
• RNA seq on patient bloods, validate proteomics and allow for pathway analysis
• Modelling of routine blood data from Glasgow trauma centre, validate initial modelling and compare bloods closer to initial injury